The film is a love letter to journalists set in an outpost of an American newspaper in a fictional 20th Century French city and brings to life a collection of stories published in The French Dispatch magazine. The cast includes Benicio Del Toro, Frances McDormand, Jeffrey Wright, Adrien Brody, Timothée Chalamet, Léa Seydoux, Tilda Swinton, Mathieu Amalric, Lyna Khoudri, Stephen Park, Owen Wilson and Bill Murray.